It seems there will be some drama with Callie on the next episode of ABC's Grey's Anatomy.

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"Meredith hires a research assistant to help with her portal vein project, and a scorned Callie gives Derek quite the shock," the episode synopsis for "We Gotta Get Out Of This Place" reads.

It's unclear if Callie's bitter feelings have to do with Meredith or with Arizona, with whom she's recently had a turbulent relationship.

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After her leg was amputated almost two years ago, Arizona's behavior shocked fans, especially the times she cheated on Callie.

Jessica Capshaw, who plays Arizona, recently spoke with TV Line about what prompted the affair and explained that her character is seeking redemption.

"There was someone outside of her little world that actually thought she was, like, a hot little piece. Someone who didn't know her as the whole person she once was or the disabled person she is now. And then it was just a rabbit hole. And this season has been about her trying to figure out how to climb out of the rabbit hole," she said.

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In the meantime, the next episode will also focus on Shane as he assists in screening candidates for Cristina's clinical trial.

In the process, he will meet a young pregnant mother. The new face, played by Keke Palmer, will seek Shane's help.