Actress Kelly McCreary is coming back to Grey's Anatomy this fall to play Meredith's half-sister and the first photo from set was released.

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Ellen Pompeo, who plays Meredith Grey, shared a photo of the two smiling together on Instagram. "Sister from another Mister?? @shondarhimes @kmccrearynyc," she wrote as the caption.

The season 10 finale revealed that Margaret "Maggie" Pierce, Grey Sloan Memorial Hospital's new head of cardio was Meredith's half-sister. Their mother Ellis Grey put her up for adoption without Margaret's father, Dr. Webber (James Pickens Jr.), knowing.

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Kate Burton, who plays both their mothers, will also reprise her role this fall, TVGuide.com reported.

"It's going to be interesting to see how it plays out," executive producer Shonda Rhimes previously told the website of the situation with Meredith's half-sister. "Because we've all known about it for so long, it's always been layered in. It's not a thing where we're going in and backdating. It's literally always been layered into the story line. We can literally go back and pull out moments of the show and I'm excited to do so, and point out where it was talked about. It's not going to be so hard to do."

In the meantime, Meredith will also have to deal with her husband, Derek (Patrick Dempsey) who left for a new job in D.C. Meredith, who feels she's been put last, will change her mindset this season.

"The idea that she has set back her career to deal with the kids and let him shine is also very frustrating for her as well. She's got a chance to step forward and say, 'I'm not going to do that anymore,'" Rhimes recently told The Hollywood Reporter.

Season 11 of Grey's Anatomy premieres on Thursday, Sept. 25 at 8/7c on ABC.

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