Will Ferrell called Kristen Stewart a "trampire" for cheating on Robert Pattinson Thursday in a visit to Conan.

A joking Ferrell reacted to the news of Stewart's affair with Rupert Sanders on Conan where he was inconsolable.

"I've never seen you like this," O'Brien told Ferrell. "What's the problem?"

When Ferrell brought up Stewart and Pattinson's breakup he burst into tears.

"What they had was so special Conan, you don't even know what they had. They were in love. And she just threw it all away!" Ferrell joked crying.

When O'Brien tried to console him saying it was going to be fine, Ferrell got more upset.

"It's not going to be fine, ever!" he shouted."What they had was so special, you don't even know! You would never know."

"I've been in love," O'Brien objected.

"Not like them," Ferrell continued indignant."She is a trampire. That's what she is."

Ferrell seemed to be making fun of "Twilight" fans' reactions to Stewart's affair with her "Snow White" director Sanders. The news shocked "Twilight" fans all over the Internet and several of them have turned to social media to express their sadness and dissappointment at the incident.

Watch Ferrell's Reaction to the Break-Up on Conan : 

Tags: kristen stewart rupert sanders