The new season of "Grey's Anatomy" began on Thursday, Sept. 27, and there is a lot in store for the major relationships among the doctors at Seattle Grace.

While Sara Ramirez has not revealed much about the future of Callie's relationship with Arizona (Jessica Capshaw), she did say that she hopes fans "will continue on this journey with us, because it's definitely going to be an intense one," according to Hollywood Life.

Arizona survives the plane crash, but she is missing one leg, which then puts her into a state of depression that Callie tries to get her out of. Gather.com also revealed that Arizona blames Callie for losing her leg, because Callie promised her she would not let he doctors do an amputation.

The couple will face many difficulties, however, an extended promo video for the second episode (shown below) features a shower scene betweeen the two, which might help their relationship flourish.

Ramirez also said that Callie will put a lot of pressure on herself this season to help Derek with his arm injury.

When we saw Meredith Grey in last season's finale, she had just experienced the death of her sister, her husband was severely injured and she was by her best friend Cristina's side awaiting rescue from a plane crash, along with her co-workers.

Traumatizing?

Well, "Grey's Anatomy" executive producer, Shonda Rhimes, said not really.

"We're not coming back to a bunch of traumatized people, though flying is pretty much out of the question for any of them," she said to TV Guide. "I would say Meredith is an ultimate survivor. She's been through the shooting, and now she's been through the plane crash. Their attitudes are very different."

After experiencing the loss of her sister, Lexie, in last season's finale, Rhimes said that Meredith will be "a very different person" in season nine.

And what about the love of her life, Derek?

Patrick Dempsey's character on "Grey's Anatomy" faced a severe arm injury on last season's finale from the place crash.

"We're going to watch what happens to a doctor who can temporarily no longer perform surgery," Rhimes said. "And what do you do and how do you overcome this? Derek is being pretty heroic about it, which is interesting."

Additionally, Dempsey said, "The first couple of episodes, he's trying to perform surgery, and it's not working, so he has to make an adjustment."

Big the biggest reveal yet was given by TV Guide,who said the following about Derek in season nine of the show:

"Now that he's unable to operate, Derek will turn to teaching the interns. 'Derek has to try and find his peace with that,' Kevin McKidd tells us. 'He doesn't get to cut anymore, but he gets to be this amazing teacher. Owen helps him learn how to be a teacher again.' "

Rhimes said this will be the "season of romance." 

A slow reconciling of Cristina and Owen's relationship is also confirmed to take place, as they start to reignite their passion and remember how much they love each other. A hint of that was shown in the season's second episode, where Cristina returns from the plane crash in somewhat of a catatonic state but then becomes violent when doctors try to examine her for injuries. Owen then tries to relax and comfort her.

In the premiere episode, we saw Cristina start as an attending physician at her new hospital in Minnesota. She did not get along so well with her co-workers and viewers were left asking, when will she return to Seattle Grace?

Watch season nine, episode two of "Grey's Anatomy" on Oct. 4 on ABC.

Tags: greys anatomy patrick dempsey ABC