Supernatural's Castiel and Crowley will be of little help to the Winchesters when season 11 begins.

'Supernatural' Season 11 Spoilers: The Darkness Is The Biggest Threat Since Lucifer? Jeremy Carver Teases New Evil

Tapped in the Impala and besieged by the darkness, Sam (Jared Padalecki) and Dean (Jensen Ackles) closed out season 10 in a fairly precarious position. Castiel (Misha Collins) and the King of Hell (Mark Sheppard), however, may be in even worse shape thanks to a severely ticked off Rowena. Needless to say, the angel and the demon will have to rescue themselves before they can focus on correcting the hunters' latest mishap.

Rowena (Ruth Connell) absconded with the Book of the Damned at the end of "My Brother's Keeper" (that's defiantly going to come back to bite Team Free Will on their collective derrieres), but before she rode off into the sunset, the witch placed the deadly guard dog spell on Cas in an effort to kill her son once and for all (see video below).

'Supernatural' Season 11: Crew Teases San Diego Comic-Con Clip, What Should Fans Expect?

"Based on what happened in that room, both of these guys have far bigger things to deal with than the boys at the top of the season," executive producer Jeremy Carver told TV Guide Magazine ahead of the series' San Diego Comic-Con appearance.

Find out if both the Crowley and Cas manage to survive Rowena's wrath when Supernatural returns to The CW on Oct. 7 at 9 p.m. ET.