The Grey's Anatomy cast has changed a bit over the years.

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Dr. Derek "McDreamy" Shepherd (Patrick Dempsey), was killed off in the latest season, but other characters have simply left, still alive.

Katherine Heigl's Grey's Anatomy character Dr. Izzie Stevens would be amongst those characters that are still living. Izzie appeared in the first six seasons of the medical drama and her storyline with Dr. Alex Karev (Justin Chambers) never really concluded with a sense of closure for viewers.

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In recent months, Heigl spoke out about not returning for the upcoming season to reprise her role of Izzie.

She told Entertainment Tonight, "There is not [a chance]" in regard to her return.

Showrunner Shonda Rhimes echoed those feelings at ABC's Television Critics Association press tour-themed bash at the Beverly Hilton according to TVLine.

She cut off the reporter with a firm "No," adding, "I'm done with that story. I've turned that idea over in my mind a thousand times and thought about how it would go. And I don't think so."

It sounds like there is no hope ever for the return of Izzie, but at least Rhimes and Heigl are at least on the same page considering when Heigl left the series there were rumors floating that she was on bad terms with the showrunner.

Grey's Anatomy will premiere its twelfth season on Sept. 24 at 8 p.m. ET.