Ja Rule and 50 Cent have had beef since the late 90s and it doesn't appear as if they two are going to make peace anytime soon.

The two rappers have reignited their years-long feud after Ja Rule went on a Twitter rant against 50 Cent in retaliation to the "In Da Club" hitmaker's comments in a recent radio interview.

50 Cent's Interview

It all started with 50 Cent's interview on the REAL 92.3 Big Boy's Neighborhood show on Jan. 18. The rapper, whose real name is Curtis Jackson, appeared on the radio show with O'Shea Jackson Jr. and Pablo Schreiber to promote his new action thriller Den of Thieves.

During the interview, Jackson Jr. brought up the topic of Ja Rule and said that when he met 50 Cent for the first time, he told him he really liked Ja Rule as an artist, which made the latter laugh. Jackson Jr. noted that 50 Cent then walked over to his grandma's car and threw out the Ja Rule CD out the window.

The host then asked 50 Cent if he had run into Ja Rule in recent times or if they've had any "on-sight type stuff." To which the rapper replied, "I'll put him to bed."

Ja Rule's Twitter Rant

50 Cent's comments did not sit well with Ja Rule, who took to Twitter to post a series of expletive-laced tweets dissing Cent.

"Fun hip-hop FACT: @50cent is P--SY..." he tweeted.

One of his followers then asked him, "Lol you sure you want to do this ? You remember what happened last time???"

"Yeah I do @50cent got beat up, stabbed and shot what do you remember???" he responded.

The rapper then went on to post several other scathing tweets aimed at his archrival. Below are some of the tweets from Ja Rule's explosive Twitter rant.

50 Cent And Ja Rule's Feud History

The two rappers have had bad blood ever since 50 Cent claimed that Ja Rule wrongfully accused him of stealing his jewelry in 1999. However, the latter maintained that he and 50 Cent started feuding after the rapper confronted him for filming projects in the same locality because he was jealous.

50 Cent dissed Ja Rule in his track "Life's on the Line" with the line "It's murdah!" The two were also involved in a physical altercation at an Atlanta hotel as revealed in an excerpt from Ja Rule's memoir Unruly: The Highs and Lows of Becoming a Man.

A rapper named Ramel "Black Child" Gill from Ja Rule's Murder Inc. stabbed 50 Cent in March 2000. The attack was believed to be the result of 50 Cent's beef with Ja Rule. Murder Inc. CEOs Irv Gotti and Chris Gotti were initially charged with the assault but the charges were later dismissed when Gill confessed to the stabbing.