Supernatural's Castiel won't be far less hesitant than Sam to end Demon Dean's life during season 10.

'Supernatural' Jensen Ackles On 'Difficult' Transition To Demon Dean, 'Womanizing Party Animal'

The angel has risked life and limb to save Dean Winchester (Jensen Ackles) in years past, but Cas (Misha Collins) will take a slightly different tune while dealing with the hunter's demonic alter ego.

"Even though it might be hard to hear, it might be hard to say, he tells Sam, 'Listen, you know what you have to do if things don't go right,'" Ackles told TV Line.

What Is The State Of Heaven In 'Supernatural' Season 10? Jeremy Carver Explains

That doesn't mean Cas will entirely give up on his friend. Despite his failing grace, the angel will spend his energy searching for hell's newest demon.

"He's very impaired. So he's just getting weaker and weaker," Collins explained to Ksite TV. "He's not really human, but his powers are very depleted and he's sick."

Do you think either Sam (Jared Padalecki) or Cas would really have the courage to off Demon Dean, or will they continue to go to the ends of the earth to find a cure? Sound off in the poll below!

Find out more when Supernatural returns to The CW on Oct. 7 at 9 p.m. ET. Click the video below to see a glimpse of Sam and Dean's episode 3 reunion.