Supernatural's Rowena and Dean will go head-to-head in "Inside Man."

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Rowena's stirring up trouble and the Winchesters can't have that, can they? Looking to take down the Grand Coven and get her own followers, Crowley's mother will be on the move in episode 17.

"Sam (Jared Padalecki) and Castiel (Misha Collins) follow up on a lead about the Mark of Cain," The CW teased. "Dean (Jensen Ackles) and Rowena (guest star Ruth Connell) meet."

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Rowena's spat with Crowley caused her to pack her bags at the end of "The Executioner's Song," but she won't hit the road until "Inside Man." Photos from set (view here) show the centuries old occultist walking chin up down a foggy road while Dean can be seen running nearby (see image here).

If you remember how well their last meeting went, another encounter between the hunters and the witch is definitely cause for concern. According to director Rashaad Green, Rowena and her son put on a can't miss performance.

"I can tell you that [Mark Sheppard] and [Ruth Connell] are absolutely riveting!" Green teased on March 4.

Meanwhile, it looks like Sam and Cas will turn to Metatron in their quest to remove the Mark of Cain. Collins was seen filming at Ladner's Harbour Park sandbox entrance to heaven while Green was at the helm, according to YRV Shoots, and a preview for the second half of season 10 shows the hunter and the angel threatening the scribe (see video below).

Find out more when "Inside Man" airs April 1 at 9 p.m. ET on The CW.

Supernatural will return on a new night starting March 18.