Lizzie Borden may be the least of the Winchester's worries when bodies start piling up on a ghostly Supernatural.

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At first blush the upcoming "Thin Lizzie" case will look like an open-and-shut haunting, but Sam (Jared Padalecki) and Dean (Jensen Ackles) will soon realize there might be something far more sinister at play. Even as the pair travels to Lizzie Borden's Massachusetts home, they can't escape the Darkness.

"While they're investigating that, however, they're going to get a rather rude surprise - or awakening, as it were - as to what the Darkness has been up to while being a growing girl," executive producer Jeremy Carver explained in a preview.

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Is Amara behind the killings? Is her presence merely causing the paranormal to shoot off the charts or could her penchant for stealing souls be having a rather adverse affect on the population? All the Winchesters know for sure is that the pesky Mark of Cain will crop up in some strange places as episode 5 progresses.

Sounds like this case will require something a little stronger than your standard salt and burn.

Join the hunt when Supernatural airs Wednesdays at 9 p.m. ET on The CW.

Tags: supernatural television the cw