Christina Applegate Opens Up About Wearing Diapers While Fighting Multiple Sclerosis

Christina Applegate openly revealed her use of diapers as she contends with multiple sclerosis (MS).

During a joint interview with PEOPLE, the 'Dead to Me" star and her close friend Jamie-Lynn Sigler, who also battles MS, discussed the challenges associated with the autoimmune disease.

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"Well, you pee ... in your pants," Applegate, 52, said. "Because you probably can't get to the bathroom in time. So yeah, diapers."

According to the publication, Applegate, known for her role of Kelly on "Married... with Children," disclosed that she was diagnosed with MS in 2021 but suspects she had it for "six or seven years" prior, as revealed on 'Good Morning America' this week. During the interview, she pulled down the waistband of her jeans to display a floral-adorned diaper she was wearing.

Sigler, who disclosed her MS diagnosis at age 20 back in 2016, added that she isn't fond of the available diaper designs.

"We have a bone to pick with the designers, because who wants a beautiful flower on your diaper? It should really say, 'F**k my life,'" she quipped.

Applegate and her counterpart, the 42-year-old 'The Sopranos' alum, maintain a positive outlook on their condition, humorously highlighting some of the "perks" that come with having MS.

"First of all, parking is awesome," remarked the 'Samantha Who?' star, to which Sigler concurred, "There could be a cure for MS, and I will not give up my handicap placard. We earned it!"

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"We're in two very different places with MS, but we help each other. Christina opened me up," Sigler said. "I didn't realize how desperately I needed to stop trying to be perfect. One thing I haven't done in the last 23 years is admit it was hard, because I didn't want to let anyone down."

Applegate, describing her struggle as "s****y," highlighted that she can be entirely candid with Sigler because they both understand the same pain.

"Multiple sclerosis (MS) is a long-lasting (chronic) disease of the central nervous system," John Hopkins Medicine reports, calling the disease "unpredictable."

"It is thought to be an autoimmune disorder, a condition in which the body attacks itself by mistake."