While April's relationship with Jackson will be a main focus when Grey's Anatomy returns to TV, another couple is also faced with some conflict.

"In the first episode back, which picks up right after the wedding, you see Jo being kind of a rock for Alex because he's furious about what Shane has done to his dad," Camilla Luddington, who plays Dr. Jo Wilson on the show, told TV Line.

"He's distraught by it. And she's there for him. And she's also ready to go [toe-to-toe] with Shane. She hates Shane. She's not for him staying at the hospital. So you see her get closer to Alex through that."

When operating on Alex's father, Dr. Shane Ross had a psychiatric episode and thought he was operating on Heather, a Grey Sloan Memorial Hospital intern who died.

April's Choice Between Jackson And Matthew Will Leave 'A Lot Of Regrets'?

As for the fate of fate of Alex's father, James Evans, also known as Jimmy, TV Guide offered some answers.

"He's not dead... yet. We'll actually meet his estranged wife (played by Victorious alum Susan Chuang), who is lured to Grey Sloan Memorial under false pretenses in the midseason return," the website said. "Suffice it to say, she's about as happy with Jimmy as Alex has been."

In other spoilers, involving Alex's lady Jo, the doctor will have to deal with some serious baby drama and she will get attached.

"Stephanie and Jo are out in the back of the hospital by the dumpsters, which is the new cool intern hangout, and Stephanie accidentally kicks a box, and there's a baby in it," Luddington previously told TVLine.

"And so we find this dumpster baby, which, of course, is very difficult for Jo because she has abandonment issues. And she is not on the case, and she really wants to be working on it."