Alex Karev's father will be make an appearance on season 10 of Grey's Anatomy and will be played by a former Dexter star, the actor revealed.

James Remar talked about his role on ABC's long-running medical drama with Zap2It on Sept. 12. He will star on the show as someone who is more than just some random patient checking in to Grey Sloan Memorial Hospital. He will play the estranged father of Alex (Justin Chambers), who in the season 9 finale made out with his intern Jo Wilson (Camilla Luddington) after a long love-hate relationship.

"I play the father of one of the doctor's on the show, Justin Chambers' character [Alex Karev]," Remar said. "He's a guy that's had a very rough life, a lot of drugs. So it's not an easy reunion."

"I do start out as a patient," Remar added.

Remar has played Dexter's adopted father, Harry Morgan, since season 1 of the show. The actor is also known for his role as Richard on Sex and the City and recently guest-starred on Wilfred, Hawaii Five-0 and The Vampire Diaries.

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Speaking in August about her character's personal relationship with Alex, Luddington was optimistic about their future in season 10.

"There's an exploration of where it goes between Alex and Jo this season. I'm excited to move on to a happier, healthier Jo," she said.

The season 10 premiere will pick up right where last season left off with Grey Sloan Memorial Hospital struggling to treat patients during a super-storm. A giant mudslide injures a group of first responders that then come to the hospital for help. The first episode will also highlight the live triangle Jackson Avery (Jesse Williams) finds himself in, and Callie Torres (Sara Ramirez) and Arizona Robbins (Jessica Capshaw) have to work together in the wake of the latter's infidelity.

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Alien's Veronica Cartwright will guest-star in the premiere as a victim of the mudslide, whom Derek Shepard (Patrick Dempsey) will treat.

Season 10 of Grey's Anatomy premieres with a two-hour episode on Thursday, Sept. 26 on ABC.