Amy Schumer's wildly successful year could lead to a big Emmy upset in September.

The Big Surprises & Snubs From This Year's Emmy Nominations

Schumer is coming off a dynamic weekend at the box office for her new movie Trainwreck and riding high with a relatively surprising Emmy nomination last week.

Schumer was nominated for Outstanding Lead Actress in a Comedy Series for her Comedy Central series Inside Amy Schumer. She is nominated against Edie Falco from Showtime's Nurse Jackie, Lisa Kudrow from HBO's The Comeback, Julia Louis-Dreyfus from HBO's Veep, Amy Poehler from NBC's Parks and Recreation and Lily Tomlin from Netflix's Grace and Frankie.

Amy Schumer's 'Trainwreck' Dominates Box Office With 'Ant Man' And 'Minions'

Inside Amy Schumer was nominated for six other Emmy Awards, including Variety Sketch Series, Directing, Writing and Guest Actor in a Comedy Series for Paul Giamatti.

The show constantly went viral throughout the year, particularly through Schumer's sketches on the topic of women in the media. Her new movie Trainwreck showcases her bawdy yet sharp humor and took in over $30 million at the box office in its opening weekend, an impressive feat considering her presence has mostly been on television.

Schumer spoke about her success to Entertainment Weekly after the Emmy nominations were announced Thursday.

"I can't catch my breath. We were jumping up and down on the bed screaming, we're so excited. My sister's a writer on the show and we got nominated for writing, and I'm especially moved and excited about getting nominated for directing." she said. "That's really special for me. And then Paul Giamatti! It's so cool when someone does you a favor, it's such a reward."

Schumer could very well win the Emmy for Lead Actress in a Comedy Series due to her incredible year plus the quality of her performance in her show. With Trainwreck in theaters during prime Emmy voting time, she could really benefit from the popular vote.

Many past actresses who have benefited from this. Melissa McCarthy of CBS's Mike & Molly, who won her Emmy in 2011 the same year as her breakout in Bridesmaids. Similarly, Katherine Heigl of ABC's Grey's Anatomy won her Emmy in 2007, the same year she starred in Knocked Up.

Schumer will likely face competition from other beloved actresses like Poehler and Louis-Dreyfus, but will her breakout year elevate her above them? Only time will tell.

The Primetime Emmys will take place Sunday, Sept. 20 at 8 p.m. ET/PT on Fox.

Meanwhile, Trainwreck is in theaters nationwide now.