Reign is about to come across one of its biggest predators of all that no one will be able to fight with weapons or words.

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On Wednesday, The CW Television Network posted a clip of a scene that features Megan Follows, who plays Queen Catherine on the series. She mentions that while everyone has a lot going on, the one force that everyone will have to be cautious of is the plague.

"There's a lot of different forces at work, and one which is sort of greater than anybody and makes everyone vulnerable is encroaching this fear of the plague," Follows said.

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The clip continues to play a scene from the series where the actress mentions how it's going to affect the characters.

"It's obviously a very real threat for all of us," she said.

The actress recently spoke to KSite TV about what she knows so far about the second season. Based on her words, it'll likely be something for fans to look forward to.

"Catherine was a very, very powerful woman, whose power had been - not really in the shadows, but she had to be very careful. So, it's going to be interesting," Follows said. "She became Queen Consort. She got it into her, basically, contract, that she would be Queen throughout the reigns of her sons. It's going to be really interesting to see where we go with it."

Reign Season 2 is set to premiere on Thursday, October 2 at 9 p.m. ET on The CW.

Check out Follows' interview below.