Giuliana Rancic spoke out about her weight in an interview.

Giuliana Rancic Slammed On Instagram For Being Too Thin

After receiving backlash on Instagram upon sharing a photo of herself and son Duke, the E! News host has revealed her thoughts on fans' criticism, and explained why it's difficult for her to put on weight.

"They were accusing me of every eating disorder. I thought to myself, 'God, if someone really thought I had an eating disorder, what a horrible way to approach it,' " the 40-year-old Rancic revealed to PEOPLE Magazine on Wednesday.

Does 'Scary Skinny' Giuliana Rancic Need Rehab?

As for why Rancic is so thin, she claims it's a result of cancer-suppressing medication, which she has been taking since 2012. While her weight loss was initially a major concern for Rancic, her oncologist, Dr. Dev Paul of Rocky Mountain Cancer Centers in Denver, assured her that weight loss is normal when taking the medication.

"It's really hurtful. I'm sorry that some people think I'm disgustingly skinny, as they put it, but there's nothing I can do. I'm lucky that I even have the type of cancer that reacts to the medicine," Rancic explained.

"I eat more than any of my friends," she continued. "I eat a very robust, healthy, balanced diet and dessert almost every night. I'm not hiding from anything. I look in the mirror and it's hard for me. I am really thin. I want to look fit and beautiful and sexy, and I can't."

Tags: Giuliana Rancic weight E!