Supernatural's Mark of Cain is a deadly nuisance, but the demon tramp stamp isn't the big bad of season 10.

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Sam (Jared Padalecki) and Dean (Jensen Ackles) have already traveled halfway through the season without knowing what kind of boss battle will throw them into the summer hiatus. Fortunately - or unfortunately, depending on how you look at it - the Winchesters' next major problem will quickly emerge over several upcoming episodes.

"Really the big bad hasn't come to fruition yet," Ackles teased, according to The Hollywood Reporter. "I believe it will; I believe they're building toward that, and we're going to start to see it in the next few episodes."

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With the Grand Coven bearing down on Rowena (Ruth Connell), it sounds like witches may become the hunter's biggest external enemy for season 10. Until then, however, Dean has far more pressing matters to attend to - even if he is apparently powerless to conquer them.

"So that being said, I think [the Mark] is his cross to bear right now," Ackles explained. "It's a bit of a steady decline - a slow deterioration - for Dean. It's a ticking time bomb, and we're really starting to realize there's no way to put the fuse out."

Find out more when Supernatural airs Tuesdays at 9 p.m. ET on The CW. Click the video below to see a preview for the series' next episode, "Halt & Catch Fire."