Screenwriter Nora Ephron died Wednesday at the age of 71, leaving a hole in the hearts of many actors who had worked with her.

The three-time Oscar-nominated writer and director was best known for the hit films "Bewitched" (2005), "Sleepless in Seattle" (1993) and "When Harry Met Sally" (1989).

The last movie Ephron worked on was "Julie & Julia" about the late chef Julia Child played by Meryl Streep. Streep earned a Best Actress Oscar nomination for her role as Child.

Many celebrities went public and used social media or released press statements to express their condolences for the beloved and humorous writer.

Longtime friend Streep wrote in an email to The New York Times: "Nora just looked at every situation and cocked her head and thought, 'Hmmmm, how can I make this more fun?'" 

Nicole Kidman, who collaborated with Ephron on "Bewitched" (2005), told the Huffington Post: "I am so grateful that she was my friend and we had the opportunity to work together. My thoughts and love are with her family at this time. I will never forget the dinners, games and laughter we all shared."

Billy Crystal who co-starred with Meg Ryan in her first hit film "When Harry Met Sally" (1989) released a statement to TMZ: "I am very sad to learn of Nora's passing. She was a brilliant writer and humorist. Being her Harry to Meg's Sally will always have a special place in my heart. I was very lucky to get to say her words."

Tom Hanks, who starred in her hit films "Sleepless in Seattle" (1993) and "You've Got Mail" (1998) said: "Nora Ephron was a journalist/artist who knew what was important to know; how things really worked, what was worthwhile, who was fascinating and why..."

Actress Juliette Lewis wrote on her Twitter account: "So sad to hear bout Nora Ephron. We did a movie called "Mixed Nut"s when I was 20. She was funny intelligent and loving. One of a kind."

Actor Steve Martin tweeted: "She was the one you wanted to read, to listen to, to be in the company of. Nora Ephron. Incomparable wit; delightful friend. Sadness reigns."

Other celebrities who didn't have the opportunity to work with Ephron also took to Twitter to share their sentiments.

 "R.I.P. Nora Ephron... Funny, charming, witty, full of heart, and one of the greatest who put it all down in timeless, quotable classics," wrote Justin Timberlake.

"Nora Ephron...thank you for your ground breaking contributions for women in the film industry. You have truly paved the way. With respect..." wrote Jessica Biel.

"If a Nora Ephron movie is on, I always stop and watch. Her movies were like comfort food for the soul. We will miss her…," wrote Christina Applegate.