Women took centerstage at the Shrine Auditorium in Los Angeles with Kristen Bell as the show's first-ever host and a lineup of all-female presenters.
The evening proved that #MeToo and Time's Up movements will remain a central focus throughout Hollywood's awards season.
"I'm not the first female host. I'm the first host. The fact that a female was chosen to be the first one means my genitals become irrelevant," Bell said.
Saturday Night Live's Maya Rudolph presented the first award of the evening for Best Male Actor in a Comedy Series. William H. Macy took home the award for the third time for his role in Shameless.
Julia Louis Dreyfus received the award Best Female Actress in a Comedy Series for her role in Veep. Dreyfus's co-stars accepted the award in her honor. According to Today, Dreyfus might have been home recovering from breast cancer treatment.
Dreyfus also celebrated another win when the cast of Veep took home the award for Outstanding Performance by an Ensemble in a Comedy Series.
Allison Janney received the award for Outstanding Performance by a Female Actress in a Supporting Role for her role as LaVona Golden in I, Tonya.
As for the males, Sam Rockwell received the award for Outstanding Performance by a Male Actor in a Supporting Role for Three Billboards Outside Ebbing, Missouri.
Big Little Lies actor Alexander Skarsgard received the award for Outstanding Performance by a Male Actor in a Miniseries or Television Movie. Nicole Kidman took the award for Outstanding Performance by a Female Actress in the same category. Kidman is a ten-time nominee, but this was her first time receiving a SAG award.
Claire Foy received the award for Outstanding Performance by a Female Actor in a Drama Series for Netflix's The Crown.
The This is Us cast were the winners of the Outstanding Performance by an Ensemble in a Drama Series.
Gary Oldman took home the award for Outstanding Performance by a Male Actor in a Leading Role in Darkest Hour.
Three Billboards Outside Ebbing, Missouri landed the award for the Outstanding Performance by a Female Actress in a Leading Role. Frances McDormand took home the award.
Rita Moreno presented Morgan Freeman with the Lifetime Achievement Award. Freeman is the 54th recipient at the 2018 SAG Awards. The moment was cherished between Moreno and Freeman as they are longtime friends and Electric Company colleagues.
While on stage, Freeman stated that having the opportunity to receive the award was beyond an honor and a place in history.
Sterling K. Brown also had another monumental moment in his career. Brown is the first ever African-American actor to receive the award for Best Performance by a Male Actor in a Drama Series for This Is Us.
While on stage Brown thanked his co-stars and joked about how happy he was that they aren't anything like the family from Get Out. Brown went on to say how grateful he was to be able to work with his wife, Ryan Michelle Bathe.
"You're the best scene partner a brother's ever had," Brown said.